DRAGEN (Dynamic Read Analysis for GENomics) Array secondary analysis is a powerful bioinformatics software for Infinium array-based assays. DRAGEN Array uses cutting-edge data analysis tools to provide accurate, comprehensive, and highly efficient secondary analysis to maximize genomic insights and meet your research needs.
DRAGEN Array
Enable accurate, comprehensive, and efficient genotyping, PGx CNV calling, and star allele annotation for Infinium microarrays
DRAGEN Array v1.0 | Features include:
- Single nucleotide variant (SNV) genotyping analysis from any human Infinium microarray.
- Pharmacogenomics (PGx) analysis pipeline including PGx copy number variant (CNV) calling, star allele calling, and metabolizer status for Infinium Global Diversity Array with Enhanced PGx BeadChips.
- Additional information and full list of features can be found in the release notes.
Overview
Accurate results
Greater than 99.5% genotyping accuracy and 95% PGx CNV accuracy1. Additionally, with a few simple commands, accurately determine hard to discern pharmacogenomic (PGx) genes like CYP2D6 with greater than 98% call rate.2
Comprehensive coverage
PGx CNV coverage on 6 target genes across 9 target regions. PGx star allele and variant coverage across 1700+ targets for over 50 genes – detects hybrid and allele specific copy number.
Efficient analysis
Genotyping, PGx CNV calling, and star allele calling in a single platform. Genotyping variant call format (VCF) files in as little as 35 seconds per sample3, saving time for large experiments.
Cloud and local deployment
DRAGEN Array offers a local, command-line package (no specialized field programmable gate array (FPGA) server or hardware required) and a cloud-based package with an intuitive graphical user interface (GUI).
Specifications
| Variant class | Single Nucleotide Polymorphisms (SNPs) |
|---|
Applications
Example workflow
Select content
Process and scan
Track, analyze and report
DRAGEN Array
Related applications and methods
Pharmacogenomics, the study of how variations in the human genome affect our response to medications, may help reduce adverse drug reactions and medical costs.
Polygenic risk scores represent the total number of genetic variants an individual has that increase their risk of developing a particular disease.
Genomics in Drug Discovery & Development
Explore innovative genomic analysis solutions designed to inform drug discovery efforts and support development of targeted therapeutics.
Documentation
Product literature
Manuals and Support Information
Figures
Genotyping, PGx CNV calling, and star allele annotation in a single platform producing multiple output options.
DRAGEN Array Cloud Analysis, Step 1:
Navigate to 'Runs – Microarray Analysis Setup' to get started with analysis
DRAGEN Array Cloud Analysis, Step 2:
Setup analysis configuration
DRAGEN Array Cloud Analysis, Step 3:
Select sample for analysis with Import Sample Sheet, Select BeadChips, or Import IDAT Files
DRAGEN Array Cloud Analysis, Step 4:
View results
Example star allele annotation JSON file to be used in downstream processing. Provides supporting variants, missing variants and alleles tested.
Local analysis (1)
DRAGEN Array Local – star allele annotation
20109885
The cost of analysis is calculated on a per sample basis.
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Cloud analysis (2)
DRAGEN Array Cloud – star allele annotation
20109886
The cost of analysis is calculated on a per sample basis.
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ICA Basic Annual Subscription
20044874
Illumina Connected Analytics (ICA) Basic Annual Subscription. This product includes 1 year of access to ICA complimentary for TSO500 customers, including sequencing instrument connectivity, data management capabilities, access to pre-packaged tools.
ICA Professional Annual Subscription
20044876
Illumina Connected Analytics (ICA) Professional Annual Subscription. This product includes 1 year of access to ICA, including sequencing instrument connectivity, data management capabilities, access to pre-packaged tools, and the ability to create customized workflows composed of tools, pipelines, data warehouses, and notebooks.
ICA Enterprise Annual Subscription
20038994
Illumina Connected Analytics (ICA) Enterprise Annual Subscription. This product includes 1 year of access to ICA Enterprise, including sequencing instrument connectivity, data management capabilities, custom and pre-packaged analysis tools, and the Base module for data warehousing and mining. ICA Enterprise also includes optional HIPPAA BAA (US-only), single sign-on (SSO), and a service level agreement (SLA).
Illumina Analytics - 1 iCredit
20042038
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
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Illumina Analytics Starter Pack - 1,000 iCredits
20042039
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
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Illumina Analytics - 5,000 iCredits
20042040
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
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Illumina Analytics - 50,000 iCredits
20042041
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
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Illumina Analytics - 100,000 iCredits
20042042
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
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Illumina Connected Analytics
A secure genomic data platform to operationalize informatics and drive scientific insights.
iCredits for Cloud Data Storage & Analysis
iCredits are used to purchase data storage and analysis within the Illumina cloud software ecosystem. One iCredit is equal to one US dollar (USD).
References
1,2,3 - Illumina data on file, 2023.
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